LEI 10882 DE 2004 PDF

Departamento de Física, Universidade de Aveiro, Aveiro, Portugal, CICECO, Universidade de Aveiro, Publication Date (Web): September 4, .. The Journal of Physical Chemistry C (29), .. Lei Zhang, Linlin Fu, Xingxing Yang, Zuoling Fu, Xiangdong Qi, Zhijian Wu. Chem., , (26), pp – Qian Zhou, Kendall Fitzgerald, Paul D. Boyle and Wesley A. Henderson Shu Li, Zhen Cao, Yuxing Peng, Lei Liu, Yonglong Wang, Shu Wang, Ji-Qiang Wang, Tianying Yan, Xue-Ping Gao, De- Ying Song and Pan-Wen .. Journal of Fluorine Chemistry , Nature Communications volume 7, Article number: () | Download Citation . (d) Data sets cover a range of detector types, including Area Welberry, T. Diffuse X-Ray Scattering and Models of Disorder OUP Oxford () . . Chinese Academy of Sciences, Shanghai , China. Ming Lei.

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Author information Copyright and License information Disclaimer. Panel d also shows an orientation rotated by deg, revealing no significant CSPs on the opposite side of the molecule. Mao carried out sample preparation, crystallization, and biophysical studies. Find articles by Robert M. Electronic and bite angle effects eli catalytic C—O bond cleavage of a lignin model dee using ruthenium Xantphos complexes Shaw L.

Further crystallization optimization was carried out using hanging drop evaporation method. Zeolite molecular accessibility and host—guest interactions studied by adsorption of organic probes of tunable size Hendriks F.

Group publications – Inorganic Chemistry and Catalysis

This result highlights differences in the replication strategies of influenza A and B viruses. To determine whether the homodimerization interface of the Ve plays any role in viral replication, we generated a recombinant virus expressing a NS1B protein with the RA mutation that inhibits CTD dimerization.


Each measurement was made in triplicate. Nanoscale infrared imaging of zeolites using photoinduced force microscopy Fu D. Consistent with the RNA binding results obtained in the biophysical studies, the KA mutant virus is not attenuated and replicates like the wt virus Figure 4d.

Nat Struct Mol Biol. Such conserved basic surfaces are typical of nucleic acid binding sites, a prediction that we verify below. Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-beta transcription.

Unexpected RNA-binding site in the NS1B Protein from Influenza B Virus not present in NS1A

CSPs may arise simply by proximity to bound nucleic acid, rather than due to specific interactions. Associated Data Supplementary Materials. We showed that this is not the case. SAD phasing using iodide ions in a high-throughput structural genomics environment.

Group publications 2017

Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: Structural basis for suppression of a host antiviral response by influenza A virus. Less extensive chemical shift perturbations are also observed on this same face of the NS1 CTD molecule upon binding a single-strand nt RNA substrate data not shown. For all FP-binding assays, fluorescence intensity FI and FP were measured after 50 minutes of incubation at room temperature to ensure equilibrium measurements.

In order to verify this conclusion, and to dd the possibility that ,ei formation is driven by RNA binding, we also measured ssRNA and dsRNA binding activity of the ArgAla 108882 at the homodimer interface, which reduces the homodimer self association Figure 3a. However, they also interact with some different host factors.


Unexpected RNA-binding site in the NS1B Protein from Influenza B Virus not present in NS1A

Evaluating protein structures determined by structural genomics consortia. Decision-making in structure solution using Bayesian estimates of map quality: J Stuct Funct Genomics. We also thank Drs. Effects of the functionalization of the ordered mesoporous carbon support surface on iron catalysts for the Fischer—Tropsch synthesis of Lower Olefins Oschatz M. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form.

The replication of these mutant viruses was assayed in human A cells using a multiplicity of infection of 0.

Dimeric interactions observed in crystal structures may or may not occur in solution, particularly under dilute protein conditions. Xiao for helpful discussions and comments on this manuscript. The Base Case Gutterod E.

Contribution of NS1 effector domain dimerization to influenza A virus replication and virulence. Residues for which CSPs could not be determined, including Pro residues, are shown in white. Find ed by Shanshan Wang. Increasing the availability of active sites in Zn-Co double metal cyanides by dispersion onto a SiO2 support Marquez C. Critical questions in the field of influenza virus research involve elucidating the features of influenza A and influenza B viruses that d their infection mechanism s and virulence.