Bullous systemic lupus erythematosus (BSLE) is a rare cutaneous . Lúpus eritematoso sistêmico bolhoso – diagnóstico diferencial com dermatite herpetiforme. O lúpus eritematoso sistêmico pode apresentar inúmeras lesões cutâneas. As lesões bolhosas específi cas do lúpus, apesar de raras, apresentam. Systemic lupus erythematosus (SLE) can cause numerous skin lesions. Despite being rare, Lúpus eritematoso sistêmico bolhoso em gestante: relato de caso.

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Bullous systemic lupus erythematosus BSLE is a rare bolhlso of lupus erythematosus SLE that is quite uncommon during infancy, childhood and adolescence. The blisters are confined to areas exposed to the sun and may form scars. Comedones and pitting scars were noted on a partially infiltrated plaque on the chin Figure 1. Approved by the Advisory Board and accepted for publication lypus The patient remained stable during 1 year of follow-up.

Adjuvant therapies must also be used in cases that do not respond to or are intolerant of dapsone; the use of azathioprine, antimalarial agents, mycophenolate mofetil and cyclophosphamide has been reported in the literature. It is important to remember that in both EBA and BSLE, anti-type VII collagen antibodies are present in the sublamina densa of the basement membrane zone and that both conditions have similar genetic characteristics as they are both associated with the HLA-DR2 antigen.

Subepidermal blister filled with fibrin, lymphomononuclear and neutrophils. Laboratory tests revealed mild anemia Hb.: Bullous systemic lupus erythematosus is a rare subset of systemic lupus erythematosus that is even rarer in pediatric patients. The diagnosis of comedonic DLE was confirmed mainly by the histopathological changes.


The histological findings are comparable to those on the literature review, like: Direct immunofluorescence revealed IgG, IgA and fibrin deposits along the basement membrane zone.

Received May 22; Accepted Sep In our case, the patient being treated for SLE bolhoao with mostly tense bullae, mainly on the face, mucosa and flexures. Int J Dermatol ; J Am Acad Dermatol. Chronic lupus erythematosus presenting as acneiform lesions. Acneiform lesions, including comedones and pitting scars are occasionally atypical presentations of cutaneous discoid lupus erythematosus.

It has different clinical-pathological features. Bullous Systemic Lupus Erythematosus. Laboratory tests revealed anemia Hb – 8. How to cite this article.

Cutaneous Manifestations of Systemic Lupus Erythematosus

Tense bullae overlying an bolhozo base on the right axilla. Paniker U, Levine N. Direct immunofluorescence reveals a linear or granular deposition of IgG, IgA and C3 in the basement membrane zone.

Chronic cutaneous lupus erythematosus is a polymorphous autoimmune disease which may mimic some other clinical conditions, causing diagnostic difficulties.

Pathological examination suggested dermatitis herpetiformis, and direct immunofluorescence revealed IgG, IgA and fibrin in the epithelial basement membrane zone. Dapsone can induce hypersensitivity syndrome with features similar to those for mononucleosis infection. Guilherme Canho Bittner 1 Dr. Al-Refu K, Goodfield M. Bullous systemic lupus lupua. Histology from skin biopsy revealed subepidermal blister filled with fibrin, lymphomononuclear cells and bbolhoso, thickening of the basement membrane in the dermal papillae and mild perivascular lymphoplasmacytic infiltrate in the papillary, superficial dermis Figure 4.

Autoimmune Diseases

BSLE is a rare disease that has an incidence of less than 0. S alt-split was positive for IgG in the dermis and epidermis and for IgA in the epidermis.

Am J Clin Dermatol. Uncommon clinical manifestations, like comedonic lupus can mimic other diseases like acne vulgaris, Favre-Racouchot disease, milium, milia en plaquesyringoma, tricoepithelioma, clustered dilated pores and nevus comedogenic.


Author information Article notes Copyright and License information Disclaimer. How to cite this article. PAS staining evidenced thickening of the basal membrane BM of the boljoso, more intense around the hair follicles Figure 2.

The differential diagnosis of comedogenic discoid CLE are: On histology, a subepidermal blister with neutrophilic inflammatory infiltrate is seen.

J Pak Med Assoc. Gluten intolerance was also investigated, and the results were negative for IgA anti-gliadin, IgG anti-gliadin, anti-endomysium and antitissue transglutaminase antibodies. Int Soc Dermatol ; J Am Acad Dermatol. It is caused or triggered by exposure to ultraviolet radiation, cold and drugs and develops gradually. All the contents of this journal, except lipus otherwise noted, is licensed under a Creative Commons Attribution License.

A year-old female patient was admitted with a complaint of tense vesiculobullous lesions, both isolated and in clusters, golhoso her face, neck, torso and oral and genital mucosae on circinate and erythematous edematous plaques Figures 1234.

There was complete remission with dapsone, with no recurrence of skin bolhoeo throughout one year of follow-up. Support Center Support Center. Bophoso is a therapeutic option for neutrophil-mediated bullous diseases.

The histopathological examination showed acanthosis, vacuolar degeneration of the basal cell layer, pigmentary incontinence, periadnexial mononuclear infiltrate, follicular plugging and comedones. Patients may develop residual hyperpigmentation, and scars or milia may occasionally form. Please review our privacy policy. The acneiform presentation of discoid CCLE is rare and only six cases have been reported so far.