Treatment of acute promyelocytic leukemia: A single institution experience. Tratamiento de la leucemia promielocítica aguda. Experiencia de una sola institución. A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Acute promyelocytic. A leucemia promielocítica aguda (LPA) é um subtipo distinto de leucemia mieloide aguda (LMA), caracterizado pela presença de um acúmulo de promielócitos.

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The clinical significance of CD34 expression in response to therapy of patients leeucemia acute myeloid leukemia: Clinical description APL onset usually occurs in middle-aged adults where it manifests by fever, fatigue, dizziness, mild cough with expectoration, exercise-induced dyspnea, weight loss or loss of appetite.

Crit Rev Oncol Hematol. Bleeding and thrombosis in acute promyelocytic leukemia. Oral prednisone is used prophylactically, ATRA is given on an outpatient basis and adriamycin is used instead of other anthracyclines.

Tratamiento de la leucemia promielocítica aguda: Experiencia de una sola institución

Acute promyelocytic leukemia as a paradigm for targeted therapy. Thrombosis in patients with acure promyelocytic leukemia treated with and without alltrans retinoic acid. Check this box if you wish to receive a copy of your message.

Association between increased body mass index and a diagnosis of acute promyelocytic leukemia in patients with acute myeloid leukemia. Treatment of newly diagnosed acute promyelocytic leukemia APL: Loss of the tumor suppressor PML in human cancer of multiple histologic origins. The epidemiology of acute promyelocytic leukaemia. All transretinoic acid ATRA. Proposals for the classification of the acute leukaemias.


A modified AIDA protocol with anthracycline-based consolidation results in high antileukemic efficacy and reduced toxicity in newly diagnosed PML-RARalpha-positive acute promyelocytic leukemia. Semin Hematol ; The clinical course of APL has been modified in recent years, from rapidly fatal acute leukemia to one of the curable subtypes of AML.

Principles, applications and problems. Blood ; 84 Suppl.

The presumptive diagnosis of APL should be quick, because these patients are at risk for early death. Open issues on bleeding and thrombosis in acute promyelocytic leukemia. Rev Bras Hematol Hemoter. Inclusion of hemoglobin level in prognostic score provides better prognostic stratification in patients with acute promyelocytic leukemia APL.

The treatment employed differs from others in: Acute promyelocytic leukemia; arterial thrombosis; treatment; citogenetic remission.

Continuing leucemis early death rate in acute promyelocytic leukemia: Outpatient supportive therapy after induction to remission therapy in adult acute leucemiia leukaemia AML is feasible: The response of treatment was evaluated during induction, consolidation and maintenance, and the occurrence of relapse and death. Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation.

In vitro studies on cellular and molecular mechanisms of arsenic trioxide As2O3 in the treatment of acute promyelocytic leukemia: Presenting white blood cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukemia promieloxitica with all-trans retinoic acid: Differentiation therapy of acute promyelocytic leukemia with tretinoin all-trans-retinoic acid.


The slightly high mortality rates, especially early mortality, motivate studies to understand this pathology in the Brazilian context.

The roles of both consolidation therapy with CT including anthracyclines as well as the maintenance therapy with ATRA, mercaptopurine and methotrexate have been also well defined. Differential liganddependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.

Early hemorrhagic death before starting therapy in acute promyelocytic leukemia: In addition, we elected to deliver ATRA fully on an outpatient basis, thus diminishing hospitalization costs.

Leicemia chromosome abnormalities confer worse prognosis in acute promyelocytic leukaemia.

¿Qué sucede si la leucemia mieloide aguda (AML) no responde o regresa después del tratamiento?

Annexin II and bleeding in acute promyelocytic leukemia. A model of molecular target based therapy. Epigenetic gene silencing in acute promyelocytic leukemia. Brit J Haematol ; Suppl. A novel method for detection, quantitation, and breakpoint cluster region determination of t 15;17 fusion transcripts using a one- step real-time multiplex RT-PCR.

Alterations of the FLT3 gene in acute promyelocytic leukemia: Translocation 15;17 and trisomy 21 in the microgranular variant of acute promyelocytic leukemia.

All-trans retinoic acid in the treatment of acute promyelocytic leukemia. Tricks of the trade for the appropriate management of newly diagnosed acute promyelocytic leukemia.