Capitulo 1 – Download as PDF File .pdf), Text File .txt) or read online. Introducao-Bioestatística – Uploaded by. by Deborah Rumsey and if you can read in portuguese: Introdução a Bioestatística para simples mortais, by Ulysses Doria Filho) and take my. . -assassinos-e-poetas-que-sonharam-a-independencia-do-brasil-pedro-doria .

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The ART trial and how lung recruitment died. Interestingly, was inteoduo polymyxin use any of: Data and results Patients in the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group was older. Therefore, if you read an article showing a possible association between combined therapy and lower mortality and take this as true I can recommend you two books Statistics for Dummies, by Deborah Rumsey and if you can read in portuguese: In their majority, the most cited, are observational trials.

Because intrkduo had to survive our attempts to kill him as intensivists until day 5.

There it is, nebulized and intravenous are the same? This is gonna be a revolving theme here, so keep your eyes open!

Here we have a problem, Immortal Time Bias. Therefore, beer drinkers have lower mortality than sober patients. Patients were included if: Is the HCAP concept a lie?

But after a multivariate analysis the authors throw the results saying the risk of infection related mortality is 8x greater in MT ulyssfs and 6x greater in NVCT group when compared to VCT group. So, if I begin with polimyxin and just after 3 days add amikacin, this guy who recive booestatistica is the same that our 5th day drunk guy. Keep this in mind! The antibiotic dose was included in the multivariate model. For me the idea of using lower doses to avoid adverse affects might increase bacterial resistance.


Patients in the validated polymyxin combination therapy had more severe infections and more serious disease, monotherapy group was older. The primary outcome was infection related mortality, which was determined by the attending physician another bias here. Go hit the books then.

Combination therapy for non-believers, and believers too! – ICU Revisited

All these information makes me wonder about the results of the multivariate analysis. Combination therapy for non-believers, and believers too!

From a statistical point of view, the drinker only begin to exist at day Even if the patients in the VCT group were more sick, it was the only group which received adequate dose treatment. I agree that is not easy to study the same bacteria, for example, Klebsiella pneumoniae carbapenemase Gen2.

If you do agree, read the literature we have available today about combination therapy. This was a unicentric, retrospective study that from evaluated antibiotic combinations to guide therapy in patients with extensively drug-resistant gram negative bacilli XDR GNB infections of any site.

I can show you that a patient who drinks beer at 5th day of ICU have lower mortality than a patient who does not. Moving on… The eligible patients were divided in three groups: Another thing is to realize that the study compares different sites of infection and different bacterias.


Both groups with combined therapy had more infections caused by Klebsiella pneumoniae and Pseudomonas aeruginosas when the monotherapy group more Acinetobacter baumannii infections. To begin with, I can do an observational trial, either retrospective or prospective, showing that doctors who drink wine 7 days a week have more sex.

Combination therapy for non-believers, and believers too!

Nothing but the whole truth. Why I hate tramadol but sometimes use it. Recently I did a review of literature about combination therapy for multi-drug resistant bacterias and soon you will see here. Meaning, if you wanna treat upysses, do it with the right dose! Is that honest to compare this group with others?

The median of adequate treatment for monotherapy group was ZERO! Now, to study Klebsiella pneumoniae carbapenemase Gen2 causing blood stream infection and compare between monotherapy vs combined therapy? S Army — Delta associates — Eoria. The only group which received polymyxin at adequate dose was the VCT group. Take another look at the antibiotics doses table. One interesting fact is that even with lot of difference among polymyxin doses no difference in nephropathy RIFLE was showed.

And also other strange things happened.