Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Extrusion Spheronization is one of them and utilized in formulation of beads and pellets. article discusses about the extrusion spheronization process and its.

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A modification was made in the existing spheronizer S. This wet mass was then extruded through single screw extruder having 0. The 5 h release of encapsulated CBT in water was determined as 1 g of CBT was placed in ml of elementary flask containing ml of distilled water and flask was sealed with a stopper.

No significant change in percent crystallinity was observed after coating of wax. For the determination of drug content factor given in USP was used. The pellets were fed into the sample micro feeder.

On application of a specific coat, these systems can also aid in site-specific delivery, thereby spheronizstion the bioavailability of many drugs. Extrusion jacketed spheronization technique presents a faster and cheaper alternative compared to conventional coating methods whereas solvent evaporation and spray drying become very expensive and time-consuming.

Moistening the powder mixture, forming cylinder-shaped agglomerate through extrusion, breaking and rounding the extrudate to round pellets through spheronization, and drying the finished product.

Extrusion & Spheronization Pharmaceutical Technology

Support Center Support Center. The percent drug release was calculated using the following equation: Release of encapsulated choline bitartrate The 5 etrusion release of encapsulated CBT was carried out to determine whether the coating offers significant protection to the choline for its stabilization.


Formulation and evaluation of aceclofenac loaded SR matrix pellets: These endothermic peaks signify that CBT is in a pure state in pellet-based formulations. Hardness-friability index was calculated on the basis of spheronizatikn results of the friability test.

Int J Pharm Investig.

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Solid state characterization of optimized pellets formulation Particle size analysis The optimized pellets were evaluated for their particle size distribution using the laser light diffraction instrument Malvern Instruments, Mastersizer Ver. Evaluation of pellets for morphological characteristics and flow properties, assay and encapsulation efficiency.

Development of novel ibuprofen loaded solid dispersion with improved bioavailability using aqueous spheronizzation.

There was no major shifting in this peak value observed. The samples were ground thoroughly with potassium bromide at 1: Formulation optimizations Exgrusion composition of the wax coating solution and other excipients should be selected such that obtained pellets have desired physical characteristics, good encapsulation efficiency, drug content, and flow properties.

A compound microscope fitted with spheronizafion calibrated ocular diameter and stage micrometer slide was used to count at least particles Olympus, NWF 10x; Educational Scientific Stores, India. Table 2 Formulation composition for different batches.

Stability studies Stability studies of pellets containing encapsulated F5 exhibited no signs of discoloration or fishy odor development after 4M on extrusiion at accelerated conditions.

Hot-melt coating with lipid excipients. The prepared pellets were also evaluated for the parameters like bulk density, tapped density, compressibility index Carr’s indexangle of repose, and hausner’s ratio.

FT-IR spectra of F5 and F10 showed retention of all the major peaks which indicate the absence of chemical interaction between wax and drug during processing.


Fourier transform infrared spectroscopy was used to assess the interaction between drug-polymer in solid state. Moisture uptake study was conducted to check hygroscopic nature of the prepared pellets. The aspect ratio of pellets varied from 1. The peak value obtained spheronziation Choline bitartrate was used as a core material and HSO as a coating agent which coat the drug.

The size uniformity and dispersity of the microspheres were represented by span value. Hydrogenated soya spheronizqtion oil has low melting point so when it is used in other techniques such as fluidized bed processor or spray drying the material got stuck to the expansion chamber during drying process and the nozzle gun also blocked during coating process.

Food and Nutrition Board-Institute of Medicine. Dewettinck K, Huyghebaert A.

Extrusion / Spheronization

The plain CBT was found to be irregular particle size and shape with higher span value. Optimization of processing variables for extrusion-jacketed spheronization process To formulate a pellet with desired characteristics physical appearance and sphericitythe parameters such as speed of spheronization, temperature of jacketed spheronizer, and time of spheronization were varied in the range as mentioned in Table 1.

With the passage of time, significant advances have been made in the process of pelletization due to the incorporation of specialized techniques for their development.