CARCINOMA DE CELULAS DE MERKEL PDF

Merkel-cell carcinoma (MCC) is a rare and highly aggressive skin cancer, which, in most cases, is caused by the Merkel cell polyomavirus (MCPyV or MCV). Merkel cell carcinoma, also called neuroendocrine carcinoma of the skin or trabecular cancer, is a very rare type of skin cancer that forms when. Los hallazgos clínicos más característicos son el rápido crecimiento y la ausencia de dolor. Aunque el carcinoma de células de Merkel puede afectar cualquier.

Author: Tojagis Mikar
Country: Russian Federation
Language: English (Spanish)
Genre: Politics
Published (Last): 8 March 2005
Pages: 443
PDF File Size: 2.95 Mb
ePub File Size: 7.77 Mb
ISBN: 530-2-66235-512-9
Downloads: 53598
Price: Free* [*Free Regsitration Required]
Uploader: Gazshura

MCC can also occur together merkek other sun exposure-related skin cancers that are not infected with MCV i. This skin cancer occurs most often in Caucasians between 60 and 80 years of age, and its rate of incidence is about twice as high in males as in females. The antibody titer in the blood to the Merkel cell polyomavirus oncoprotein can be used as a treatment response biomarker in people that have detectable antibodies at the time of diagnosis.

Carcimoma specific staging system for Merkel cell carcinoma exists, 7 but the tumor is generally classified as: Complete excision is associated with significant higher survival rates.

What Is Merkel Cell Carcinoma?

The most frequent locations include: The case of our patient was classified initially as stage I. Similarly, most experts recommend longitudinal imaging of the cleulas, typically a CT scan, to rule out that the possibility that the skin lesion is a skin metastasis of an underlying small cell carcinoma of the lung. The lesion was excised under general anesthesia with oncological margins and the skin was reconstructed with a cervicofacial rotation-sliding skin flap Fig.

  LASER ELECTRONICS VERDEYEN SOLUTION MANUAL PDF

Sentinel lymph node biopsy SLNB detects Ceulas spread in one third of patients whose tumors would have varcinoma been clinically and radiologically understaged, and who may not have received treatment to the involved node bed. Because of MCC’s aggressive local and regional metastatic behavior, radiotherapy is commonly used to treat Merkel-cell cancer.

It is not certain whether surgical excision of the affected lymph nodes is better than radiation treatment alone. Hospital Universitario La Paz.

The virus is clonally integrated into the cancerous Merkel cells. A clinical case of Merkel cell carcinoma of the face treated with surgery and radiotherapy is reported and the literature is reviewed. Travesera de Gracia,Barcelona, Barcelona, ES, maxilo elsevier.

Merkel cells; Merkel cancer; Skin cancer. Cancer starts when cells begin to grow out of control. Archived from the original on Chemotherapy may be used to treat both primary and metastatic MCC.

Early diagnosis and treatment of Merkel-cell cancers are important factors in decreasing the chance of metastasis, after which it is exceptionally difficult to cure. They are located in the epidermal basement layer and are said to be slow action mechanoreceptors.

What Is Merkel Cell Carcinoma?

The Journal of Clinical Investigation. Other factors of poor prognosis are: Merkel cells Merkel cells are thought to be a type of skin neuroendocrine cellbecause they share some features with nerve cells and hormone-making cells. Radiotherapy at a dose of 60 Gy also has been used alone, obtaining adequate levels of local control, which supports ce characterization of this tumor as radiosensitive. A whole-body scan with thoraco-abdominal CT did not reveal systemic invasion Fig.

  AION CLERIC GUIDE PDF

El Carcinoma de Células de Merkel

Confusion with other pathologies, like basocellular carcinoma, amelanotic melanoma or cutaneous lymphomas, is common. Skin cancerEpidermis C In addition, the virus has a particular mutation only when found in cancer cells, but not when it is detected in healthy skin cells.

The authors believe that the proper approach to this type of cases should include a study by the sentinel lymph node technique to detect micrometastases. In consequence, if metastasis is diagnosed, treatment is merely palliative. The response to chemotherapy generally is of short duration and patients ultimately die from the disease.

It is generally located in the dermis and can extend to the epidermis or subcutaneous tissue. Generalized eruptive Keratoacanthoma centrifugum marginatum Multiple Solitary. Epidermal nevus Syndromes Epidermal nevus caricnoma Schimmelpenning syndrome Nevus comedonicus syndrome Nevus comedonicus Inflammatory linear verrucous epidermal nevus Linear verrucous epidermal nevus Pigmented hairy epidermal nevus syndrome Systematized epidermal nevus Phakomatosis pigmentokeratotica.