THE DIFFERENT KINDS OF PRODRUGS A. Defi nitions and classifi cations B. The carrier prodrug principle C. The bioprecursor-prodrug principle D. Other. Bioprecursor Prodrugs. Phosphorylation example –. Bioprecursor Prodrugs. We have already seen 2 examples of this: Sulfasalazine – an azo compound. Bioprecursor Prodrugs: Molecular Modification of the Active Principle Keywords: Bioprecursor prodrugs, active metabolites, oxidative activation, glucuronic.
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Bioprecursor prodrugs: molecular modification of the active principle. – Semantic Scholar
Share buttons are a little bit lower. Identify how prodrugs approach can be used to overcome certain issues with a drug candidate 4. Oxidative Activation P c. What the body does to the drug? Cancer Chemotherapy Tumor cells have a much higher growth fraction This translates into higher enzymatic activity that can be exploited Target a prodrug to these sites and exploit higher enzyme activity Example: Examples of Carrier-linked Tripartate Prodrugs.
Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Prodrugs to minimize toxicity aspirin anti-inflammatory ester derivative of prodrugss a.
Prodrugs to encourage patient acceptance clindamycin antibacterial. What the body does to the drug? Enter the body by crossing barriers Distributed by the blood to the bioprecursoe of action Biotransform.
Auth with social network: Prodrugs for Site Specificity a. Prodrugs to encourage patient acceptance clindamycin antibacterial PowerPoint Presentation: This may be helpful for increasing bioavailability, or also if the drug itself is nonspecific in its action.
Know some examples of currently used prodrugs. We think you have liked this presentation.
Disulfide reduction thiamin tetrahydrofurfuryl disulfide thiamin 3. Sum total of ALL chemical reactions in a living organism Metabolism is about the energy balance in cells, production. Enter the body by crossing barriers Distributed by the blood to the site of action Biotransform. About project SlidePlayer Terms of Service.
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Presentation Description Prodrugs, medicinal chemistry. Anti-inflammatory drug Tolmetin has a peak plasma concentration of about 1 hr.
Protect a non-specific biological environment from a drug Protect a drug from a non-specific biological environment Especially evaluated for drugs with a narrow therapeutic window especially anti-cancer agents. N-Oxidation pralidoxime acetylcholine esterase activator e. Feedback Privacy Bioprecuror Feedback. Published by Aubrey Johnston Modified over 3 years ago.
Protect a non-specific biological environment from a drug Protect a drug from a non-specific biological environment Especially evaluated for drugs with a narrow therapeutic window especially anti-cancer agents.
However, activated amides biolrecursor amides of amino acids are more susceptible to enzyme mediated cleavage. Download ppt “Bioprecursor Prodrugs”. To make this website work, we log user data and share it with processors. OK Is the passage of drug from its site of administration to its site of action through cell membranes.