Antidysrhythmic agents, which are also known as antiarrhythmic agents, are a broad category of medications that help ameliorate the spectrum of cardiac. The ultimate goal of antiarrhythmic drug therapy is to restore normal rhythm and conduction. When it is not possible to revert to normal sinus rhythm, drugs may. Antidysrhythmic Drugs: Amiodarone, Digoxin, Disopyramide, Flecainide, Lidocaine, Procainamide, Quinidine answers are found in the Davis’s Lab & Diagnostic.

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Antiarrhythmic drugs are used to:.

Antidysrhythmic Drugs | Student of Nursing Blog

Also noteworthy is that a few class II agents like propranolol also have a membrane stabilizing effect. Adenosine Digoxin Magnesium Sulfate. Since the development of the original Vaughan Williams classification system, additional agents have been used that do not fit cleanly into categories I through IV.

These drugs typically affect potassium channels and delay repolarization of action potentials phase 3. Class I agents block the rapid inward sodium channel, slow the rate of rise of phase 0, and so decrease the rate of depolarization.

Antiarrhythmic Drugs

Common adverse effects include hypersensitivity reactions, nausea, vomiting, diarrhea, dizziness, headache and blurred vision. Calcium channel blockers and beta-blockers are useful for this indication. Drugs that block slow inward calcium channels are used to reduce pacemaker firing rate by slowing the rate of rise of depolarizing pacemaker potentials phase 4 depolarization. You are commenting using your Facebook account. Class I agents are divided into three groups Ia, Ib, and Ic based upon their effect on the length of the action potential.


Interactions Are unique to each individual drug but can include the potentiation of anticoagulent activity with warfarin coumadin. Click here to see a table summarizing the types of drugs that may be used to treat different types of arrhythmias. In Symposium on Cardiac Arrhythmias Eds. Treatment and prevention during and immediately after myocardial infarctionthough this practice is now discouraged given the increased risk of asystole Ventricular tachycardia.

There are four classes of antidysrhytmics which each have a different mechanism of action. Student of Nursing Blog An informative site of nursing information. Class I drugs work on sodium channels, and are subdivided in a, b, and c classes.

Decrease myocardial infarction mortality Prevent recurrence of tachyarrhythmias Propranolol has sodium channel-blocking effects. Antidysrhythmic agents, which are also known as antiarrhythmic agents, are a broad category of medications that help ameliorate the spectrum of cardiac arrhythmias to maintain normal rhythm and conduction in the heart.

Sign in via OpenAthens. The ultimate goal of antiarrhythmic drug therapy is to restore normal rhythm and conduction.

Many attempts have been made to classify antiarrhythmic agents. Quinidine Ajmaline Procainamide Disopyramide.

Those proposed in were: Another approach, known as the “Sicilian gambit”, placed a greater approach on the underlying mechanism. Beta blocking Propranolol also shows some class I action. Abnormal automaticity is thought to occur due to reduced resting membrane potential, causing the membrane to be closer to the threshold for generating an action potential.


On the Y axis, each drug is listed, in roughly the Singh-Vaughan Williams order. Decongestants Bronchodilators Cough medicines H 1 antagonists. Email required Address never made public. Please enter User Name Password Error: Pop-up div Successfully Displayed This div only appears when the trigger link is hovered over.

Clinical Sports Medicine Collection. Antiarrhythmic agents Cardiac electrophysiology. Antidotes Contrast media Radiopharmaceuticals Dressings Senotherapeutics.

The re-entrant rhythm is less likely to interact with tissue that has become refractory. Toxicity Another adverse effect is drug toxicity. The class I antiarrhythmic agents interfere with the sodium channel. Arrhythmias generally arise as a result of abnormal impulse generation or abnormal conduction, or a combination of the two.

CV Pharmacology | Antiarrhythmic Drugs

Ventricular arrhythmias Prevention of paroxysmal recurrent atrial fibrillation triggered by vagal overactivity Procainamide in Wolff-Parkinson-White syndrome Increases QT interval.

Please note that many of the drugs comprising the first five listed classes have considerable overlap in their pharmacologic properties. These drugs also reduce conduction velocity at the AV nodebecause those cells, like SA nodal cells, depend on the inward movement of calcium ions to depolarize. Other types of antiarrhythmic drugs affect the duration of action potentials, and especially the effective refractory period.

Inhibiting potassium channels, slowing repolarization, results in slowed atrial-ventricular myocyte repolarization.

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